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” He and Munakata believe that gradual variations in how the DNA is saved could lead to a loss of fertility as Females age. If so, their exploration could pave the way in which for enhanced remedy and diagnosis of fertility troubles.
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Utilizing the GCRLE grant, Munakata and Namekawa will appear much more closely at how oocytes are genomically primed and stored for later use. They can look into the part of a chromatin remodeler in oocyte survival and fertility.
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Namekawa thinks that in human oocytes, adjustments in these styles could disrupt the sensitive choreography of genes becoming turned on and off at the appropriate instances — leaving them unprepared for fertilization or growth into nutritious embryos. Adjustments in chromatin composition as an oocyte ages may also influence just how that chromosomes segregate for the duration of mobile division.
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